Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling

Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling

Objective: Mitochondrial aconitase (ACO2) is an essential enzyme that bridges the TCA cycle and lipid metabolism. However, its role in cancer development remains to be elucidated. The metabolic subtype of colorectal cancer (CRC) was recently established. We investigated ACO2's potential role in...

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Bibliographic Details
Main Authors: Xin You, Jingyu Tian, Hui Zhang, Yunhua Guo, Jing Yang, Chaofeng Zhu, Ming Song, Peng Wang, Zexian Liu, John Cancilla, Wenhua Lu, Christophe Glorieux, Shijun Wen, Hongli Du, Peng Huang, Yumin Hu
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Metabolism
Subjects:
Mitochondrial aconitase
Colon cancer
Tricarboxylic acid (TCA) cycle
Lipogenesis
Stearoyl-CoA desaturase
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000430

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http://www.sciencedirect.com/science/article/pii/S2212877821000430

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