PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells

PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells

The PLZF transcription factor is essential for osteogenic differentiation of hMSCs; however, its regulation and molecular function during this process is not fully understood. Here, we revealed that the ZBTB16 locus encoding PLZF, is repressed by Polycomb (PcG) and H3K27me3 in naive hMSCs. At the pr...

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Bibliographic Details
Main Authors: Shuchi Agrawal Singh, Mads Lerdrup, Ana-Luisa R Gomes, Harmen JG van de Werken, Jens Vilstrup Johansen, Robin Andersson, Albin Sandelin, Kristian Helin, Klaus Hansen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
human mesenchymal stem cells
histone H3 lysine 27 tri-methylation
osteogenesis
developmental enhancer
Polycomb proteins
PLZF
Online Access:https://elifesciences.org/articles/40364

Internet

https://elifesciences.org/articles/40364

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