PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells
The PLZF transcription factor is essential for osteogenic differentiation of hMSCs; however, its regulation and molecular function during this process is not fully understood. Here, we revealed that the ZBTB16 locus encoding PLZF, is repressed by Polycomb (PcG) and H3K27me3 in naive hMSCs. At the pr...
Main Authors: | Shuchi Agrawal Singh, Mads Lerdrup, Ana-Luisa R Gomes, Harmen JG van de Werken, Jens Vilstrup Johansen, Robin Andersson, Albin Sandelin, Kristian Helin, Klaus Hansen |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-01-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/40364 |
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