BRCA1 and BRCA2 mutations and clinical interpretation in 398 ovarian cancer patients: comparison with breast cancer variants in a similar population

BRCA1 and BRCA2 mutations and clinical interpretation in 398 ovarian cancer patients: comparison with breast cancer variants in a similar population

Abstract Background Ovarian cancer is the leading cause of death worldwide among gynecologic malignancies. The recent approval of inhibitors of poly (ADP-ribose) polymerase (iPARP) in the treatment of ovarian cancer in the presence of a BRCA1/2 mutation has sparked the analysis of women with such di...

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Bibliographic Details
Main Authors: Florencia C. Cardoso, Susana Goncalves, Pablo G. Mele, Natalia C. Liria, Leonardo Sganga, Ignacio Diaz Perez, Ernesto J. Podesta, Angela R. Solano
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Human Genomics
Subjects:
Ovarian cancer
BRCA1/2 and ovarian cancer
iPARP treatment
Online Access:http://link.springer.com/article/10.1186/s40246-018-0171-5

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http://link.springer.com/article/10.1186/s40246-018-0171-5

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