Matrix Metalloproteinase-2 Impairs Homing of Intracoronary Delivered Mesenchymal Stem Cells in a Porcine Reperfused Myocardial Infarction: Comparison With Intramyocardial Cell Delivery

Matrix Metalloproteinase-2 Impairs Homing of Intracoronary Delivered Mesenchymal Stem Cells in a Porcine Reperfused Myocardial Infarction: Comparison With Intramyocardial Cell Delivery

BackgroundIntracoronary (IC) injection of mesenchymal stem cells (MSCs) results in a prompt decrease of absolute myocardial blood flow (AMF) with late and incomplete recovery of myocardial tissue perfusion. Here, we investigated the effect of decreased AMF on oxidative stress marker matrix metallopr...

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Bibliographic Details
Main Authors: Katrin Zlabinger, Dominika Lukovic, Rayyan Hemetsberger, Alfred Gugerell, Johannes Winkler, Ljubica Mandic, Denise Traxler, Andreas Spannbauer, Susanne Wolbank, Gerald Zanoni, Christoph Kaun, Aniko Posa, Andrea Gyenes, Zsolt Petrasi, Örs Petnehazy, Imre Repa, Renate Hofer-Warbinek, Rainer de Martin, Florian Gruber, Silvia Charwat, Kurt Huber, Noemi Pavo, Imre J. Pavo, Noemi Nyolczas, Dara L. Kraitchman, Mariann Gyöngyösi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
mesenchymal stem cells
translational research
cell delivery
oxidative stress
homing
intracoronary
Online Access:http://journal.frontiersin.org/article/10.3389/fbioe.2018.00035/full

Internet

http://journal.frontiersin.org/article/10.3389/fbioe.2018.00035/full

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