Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronal apoptosis in the hypothalamus: effects of neonatal alcohol

Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronal apoptosis in the hypothalamus: effects of neonatal alcohol

Abstract Background Opioid receptors are known to control neurotransmission of various peptidergic neurons, but their potential role in regulation of microglia and neuronal cell communications is unknown. We investigated the role of mu-opioid receptors (MOR) and delta-opioid receptors (DOR) on micro...

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Bibliographic Details
Main Authors: Pallavi Shrivastava, Miguel A. Cabrera, Lucy G. Chastain, Nadka I. Boyadjieva, Shaima Jabbar, Tina Franklin, Dipak K. Sarkar
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Journal of Neuroinflammation
Subjects:
MOR
DOR
Microglia
Inflammatory and anti-inflammatory cytokines
Fetal alcohol
POMC
Online Access:http://link.springer.com/article/10.1186/s12974-017-0844-3

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http://link.springer.com/article/10.1186/s12974-017-0844-3

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