Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells

Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells

Abstract Background Free fatty acid receptor 1 (FFAR1) is G-protein coupled receptor predominantly expressed in pancreatic β-cells that is activated by a variety of free fatty acids (FFAs). Once activated, it promotes glucose-stimulated insulin secretion (GSIS). However, increased levels of FFAs lea...

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Bibliographic Details
Main Authors: Sulaiman K. Marafie, Eman M. Al-Shawaf, Jehad Abubaker, Hossein Arefanian
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Biological Research
Subjects:
Palmitic acid
Lipotoxicity
Insulin resistance
Type 2 diabetes
FFAR1
mTOR
Online Access:http://link.springer.com/article/10.1186/s40659-019-0253-4

Internet

http://link.springer.com/article/10.1186/s40659-019-0253-4

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