Persistence of senescent prostate cancer cells following prolonged neoadjuvant androgen deprivation therapy.

Persistence of senescent prostate cancer cells following prolonged neoadjuvant androgen deprivation therapy.

PURPOSE:Androgen deprivation therapy (ADT) commonly leads to incomplete cell death and the fate of persistent cells involves, in part, a senescent phenotype. Senescence is terminal growth arrest in response to cell stress that is characterized by increased lysosomal-β-galactosidase (GLB1) the origin...

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Bibliographic Details
Main Authors: Michael L Blute, Nathan Damaschke, Jennifer Wagner, Bing Yang, Martin Gleave, Ladan Fazli, Fangfang Shi, E Jason Abel, Tracy M Downs, Wei Huang, David F Jarrard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5325224?pdf=render

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http://europepmc.org/articles/PMC5325224?pdf=render

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