Glycolipid and ganglioside metabolism imbalances in Huntington's disease

Glycolipid and ganglioside metabolism imbalances in Huntington's disease

We have explored genome-wide expression of genes related to glycobiology in exon 1 transgenic Huntington's disease (HD) mice using a custom-designed GLYCOv2 chip and Affymetrix microarray analyses. We validated, using quantitative real-time PCR, abnormal expression levels of genes encoding glyc...

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Bibliographic Details
Main Authors: Paula A. Desplats, Christine A. Denny, Kristi E. Kass, Tim Gilmartin, Steven R. Head, J. Gregor Sutcliffe, Thomas N. Seyfried, Elizabeth A. Thomas
Format: Article
Language:English
Published: Elsevier 2007-09-01
Series:Neurobiology of Disease
Subjects:
Gangliosides
Huntington's disease
Gene expression
Neurodegeneration
Caudate
R6/1 transgenic mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107001076

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http://www.sciencedirect.com/science/article/pii/S0969996107001076

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