Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana.

Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana.

Haemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria. It is not clear, however, how these two alleles have evolved in the West African countries where they co-exist at high frequencies. Here we use haplotypic signatures of selection to investigate the evolu...

Full description

Bibliographic Details
Main Authors: Anita Ghansah, Kirk A Rockett, Taane G Clark, Michael D Wilson, Kwadwo A Koram, Abraham R Oduro, Lucas Amenga-Etego, Thomas Anyorigiya, Abraham Hodgson, Paul Milligan, William O Rogers, Dominic P Kwiatkowski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3323552?pdf=render

Internet

http://europepmc.org/articles/PMC3323552?pdf=render

Similar Items