NOTCH1 Signaling in Head and Neck Squamous Cell Carcinoma

NOTCH1 Signaling in Head and Neck Squamous Cell Carcinoma

Biomarker-driven targeted therapies are lacking for head and neck squamous cell carcinoma (HNSCC), which is common and lethal. Efforts to develop such therapies are hindered by a genomic landscape dominated by the loss of tumor suppressor function, including <i>NOTCH1</i> that is frequen...

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Bibliographic Details
Main Authors: Pooja A. Shah, Chenfei Huang, Qiuli Li, Sawad A. Kazi, Lauren A. Byers, Jing Wang, Faye M. Johnson, Mitchell J. Frederick
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cells
Subjects:
head and neck squamous cell carcinoma
NOTCH1
tumor suppressor
mutation
synthetic lethal
phosphatidylinositol 3-kinase
Online Access:https://www.mdpi.com/2073-4409/9/12/2677

Internet

https://www.mdpi.com/2073-4409/9/12/2677

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