Imaging iron and neuromelanin simultaneously using a single 3D gradient echo magnetization transfer sequence: Combining neuromelanin, iron and the nigrosome-1 sign as complementary imaging biomarkers in early stage Parkinson's disease

Imaging iron and neuromelanin simultaneously using a single 3D gradient echo magnetization transfer sequence: Combining neuromelanin, iron and the nigrosome-1 sign as complementary imaging biomarkers in early stage Parkinson's disease

Diagnosing early stage Parkinson's disease (PD) is still a clinical challenge. Previous studies using iron, neuromelanin (NM) or the Nigrosome-1 (N1) sign in the substantia nigra (SN) by themselves have been unable to provide sufficiently high diagnostic performance for these methods to be adop...

Full description

Bibliographic Details
Main Authors: Naying He, Kiarash Ghassaban, Pei Huang, Mojtaba Jokar, Ying Wang, Zenghui Cheng, Zhijia Jin, Yan Li, Sean K. Sethi, Yixi He, Yongsheng Chen, Sara Gharabaghi, Shengdi Chen, Fuhua Yan, E. Mark Haacke
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:NeuroImage
Subjects:
Parkinson's disease
Substantia nigra
Neuromelanin
Nigrosome-1 sign
Magnetization transfer contrast
Quantitative susceptibility mapping
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811921000872

Internet

http://www.sciencedirect.com/science/article/pii/S1053811921000872

Similar Items