Sampling strategies to evaluate the prognostic value of a new biomarker on a time-to-event end-point

Abstract Background The availability of large epidemiological or clinical data storing biological samples allow to study the prognostic value of novel biomarkers, but efficient designs are needed to select a subsample on which to measure them, for parsimony and economical reasons. Two-phase stratifi...

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Bibliographic Details
Main Authors: Francesca Graziano, Maria Grazia Valsecchi, Paola Rebora
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Medical Research Methodology
Subjects:
Online Access:https://doi.org/10.1186/s12874-021-01283-0