Single-cell landscape of nuclear configuration and gene expression during stem cell differentiation and X inactivation

Single-cell landscape of nuclear configuration and gene expression during stem cell differentiation and X inactivation

Abstract Background Mammalian development is associated with extensive changes in gene expression, chromatin accessibility, and nuclear structure. Here, we follow such changes associated with mouse embryonic stem cell differentiation and X inactivation by integrating, for the first time, allele-spec...

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Main Authors: Giancarlo Bonora, Vijay Ramani, Ritambhara Singh, He Fang, Dana L. Jackson, Sanjay Srivatsan, Ruolan Qiu, Choli Lee, Cole Trapnell, Jay Shendure, Zhijun Duan, Xinxian Deng, William S. Noble, Christine M. Disteche
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-021-02432-w

Internet

https://doi.org/10.1186/s13059-021-02432-w

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