Human Bone Marrow-Resident Natural Killer Cells Have a Unique Transcriptional Profile and Resemble Resident Memory CD8+ T Cells

Human Bone Marrow-Resident Natural Killer Cells Have a Unique Transcriptional Profile and Resemble Resident Memory CD8+ T Cells

Human lymphoid tissues harbor, in addition to CD56bright and CD56dim natural killer (NK) cells, a third NK cell population: CD69+CXCR6+ lymphoid tissue (lt)NK cells. The function and development of ltNK cells remain poorly understood. In this study, we performed RNA sequencing on the three NK cell p...

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Bibliographic Details
Main Authors: Janine E. Melsen, Gertjan Lugthart, Carly Vervat, Szymon M. Kielbasa, Sander A. J. van der Zeeuw, Henk P. J. Buermans, Monique M. van Ostaijen-ten Dam, Arjan C. Lankester, Marco W. Schilham
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
natural killer cells
tissue-resident
RNA sequence
CD8+ T cells
lymphoid tissue
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01829/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01829/full

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