High-throughput mutagenesis reveals unique structural features of human ADAR1

High-throughput mutagenesis reveals unique structural features of human ADAR1

Human ADAR proteins are responsible for RNA editing, conversion of adenosine to inosine in double-stranded RNA. Here the authors report a previously unknown zinc ion-binding site in the catalytic domain of human ADAR1 using high throughput mutagenesis, biochemical assay and Rosetta-based protein str...

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Bibliographic Details
Main Authors: SeHee Park, Erin E. Doherty, Yixuan Xie, Anil K. Padyana, Fang Fang, Yue Zhang, Agya Karki, Carlito B. Lebrilla, Justin B. Siegel, Peter A. Beal
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18862-2

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https://doi.org/10.1038/s41467-020-18862-2

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