Metabolic Profiling of a CB2 Agonist, AM9338, Using LC-MS and Microcoil-NMR: Identification of a Novel Dihydroxy Adamantyl Metabolite

Metabolic Profiling of a CB2 Agonist, AM9338, Using LC-MS and Microcoil-NMR: Identification of a Novel Dihydroxy Adamantyl Metabolite

Adamantyl groups are key structural subunit commonly used in many marketed drugs targeting diseases ranging from viral infections to neurological disorders. The metabolic disposition of adamantyl compounds has been mostly studied using LC-MS based approaches. However, metabolite quantities isolated...

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Bibliographic Details
Main Authors: Chandrashekhar Honrao, Xiaoyu Ma, Shashank Kulkarni, Vinit Joshi, Michael Malamas, Alexander Zvonok, JodiAnne Wood, David Strand, Jason J. Guo, Alexandros Makriyannis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
metabolite identification
LC-MS
micro-coil NMR
adamantyl metabolism
di-hydroxyl adamantyl metabolite
CYP3A4 metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.575691/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.575691/full

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