Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression

Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression

Engineered T cells with chimeric antigen receptor (CAR) are emerging as an effective cancer therapy. Here the authors show that CAR T cells recognizing self-MHC can be ‘tuned’ ex vivo via CAR downregulation and CAR T cell death to generate a CAR T pool specifically targeting tumor cells with high MH...

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Bibliographic Details
Main Authors: Chungyong Han, Su-Jung Sim, Seon-Hee Kim, Rohit Singh, Sunhee Hwang, Yu I. Kim, Sang H. Park, Kwang H. Kim, Don G. Lee, Ho S. Oh, Sangeun Lee, Young H. Kim, Beom K. Choi, Byoung S. Kwon
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-02912-x

Internet

https://doi.org/10.1038/s41467-018-02912-x

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