Modeling temperature- and Cav3 subtype-dependent alterations in T-type calcium channel mediated burst firing

Modeling temperature- and Cav3 subtype-dependent alterations in T-type calcium channel mediated burst firing

Abstract T-type calcium channels are important regulators of neuronal excitability. The mammalian brain expresses three T-type channel isoforms (Cav3.1, Cav3.2 and Cav3.3) with distinct biophysical properties that are critically regulated by temperature. Here, we test the effects of how temperature...

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Bibliographic Details
Main Authors: Fernando R. Fernandez, Mircea C. Iftinca, Gerald W. Zamponi, Ray W. Turner
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Molecular Brain
Subjects:
Cav3
T-type
Calcium channel
Rebound burst discharge
Temperature
Online Access:https://doi.org/10.1186/s13041-021-00813-7

Internet

https://doi.org/10.1186/s13041-021-00813-7

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