Nilotinib and imatinib are comparably effective in reducing growth of human eosinophil leukemia cells in a newly established xenograft model.

Nilotinib and imatinib are comparably effective in reducing growth of human eosinophil leukemia cells in a newly established xenograft model.

We developed a xenograft model of human Chronic Eosinophilic Leukemia (CEL) to study disease progression and remission-induction under therapy with tyrosine kinase inhibitors using imatinib and nilotinib as examples. The FIP1L1/PDGFRA+ human CEL cell lineEOL-1 was injected intravenously into scid mi...

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Bibliographic Details
Main Authors: Daniel Wicklein, Nuno Ramos Leal, Johannes Salamon, Mohammed Thamer, Harald Herrmann, Peter Valent, Udo Schumacher, Sebastian Ullrich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22348015/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22348015/?tool=EBI

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