Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity

Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity

Shp1, encoded by the gene Ptpn6, is a protein tyrosine phosphatase that transduces inhibitory signals downstream of immunoreceptors in many immune cell types. Blocking Shp1 activity represents an exciting potential immunotherapeutic strategy for the treatment of cancer, as Shp1 inhibition would be p...

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Bibliographic Details
Main Authors: Darienne R. Myers, Clare L. Abram, David Wildes, Amira Belwafa, Alia M. N. Welsh, Christopher J. Schulze, Tiffany J. Choy, Tram Nguyen, Neil Omaque, Yongmei Hu, Mallika Singh, Rich Hansen, Mark A. Goldsmith, Elsa Quintana, Jacqueline A. M. Smith, Clifford A. Lowell
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
tyrosine phosphatase
phagocytosis
PTPN6
immuno-oncology
SIRPα
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.576310/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.576310/full

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