Genetic Ablation of G Protein-Gated Inwardly Rectifying K+ Channels Prevents Training-Induced Sinus Bradycardia

Genetic Ablation of G Protein-Gated Inwardly Rectifying K+ Channels Prevents Training-Induced Sinus Bradycardia

Background: Endurance athletes are prone to bradyarrhythmias, which in the long-term may underscore the increased incidence of pacemaker implantation reported in this population. Our previous work in rodent models has shown training-induced sinus bradycardia to be due to microRNA (miR)-mediated tran...

Full description

Bibliographic Details
Main Authors: Isabelle Bidaud, Alicia D’Souza, Gabriella Forte, Eleonora Torre, Denis Greuet, Steeve Thirard, Cali Anderson, Antony Chung You Chong, Angelo G. Torrente, Julien Roussel, Kevin Wickman, Mark R. Boyett, Matteo E. Mangoni, Pietro Mesirca
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Physiology
Subjects:
G-protein-gated inwardly rectifying potassium 4 (Girk4)
hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) channel
bradycardia
sinoatrial node
endurance athletes
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.519382/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.519382/full

Similar Items