The loss-of-function mutations and down-regulated expression of ASB3 gene promote the growth and metastasis of colorectal cancer cells

The loss-of-function mutations and down-regulated expression of ASB3 gene promote the growth and metastasis of colorectal cancer cells

Abstract Background Ankyrin repeat and SOCS box protein 3 (ASB3) is a member of ASB family and contains ankyrin repeat sequence and SOCS box domain. Previous studies indicated that it mediates the ubiquitination and degradation of tumor necrosis factor receptor 2 and is likely involved in inflammato...

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Bibliographic Details
Main Authors: Wu-Ying Du, Zhen-Hai Lu, Wen Ye, Xiang Fu, Yi Zhou, Chun-Mei Kuang, Jiang-Xue Wu, Zhi-Zhong Pan, Shuai Chen, Ran-Yi Liu, Wen-Lin Huang
Format: Article
Language:English
Published: BMC 2017-01-01
Series:Chinese Journal of Cancer
Subjects:
Ankyrin repeat and SOCS box protein 3 (ASB3)
Colorectal cancer
Epithelial-mesenchymal transition
Cell proliferation
Tumor metastasis
Online Access:http://link.springer.com/article/10.1186/s40880-017-0180-0

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http://link.springer.com/article/10.1186/s40880-017-0180-0

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