Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice

Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice

Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by the loss of nigrostriatal dopamine neurons. PARK2 mutations cause early-onset Parkinson's disease (EO-PD). PARK2 encodes an E3 ubiquitin ligase, Parkin. Extensive in vitro studies and cell line...

Full description

Bibliographic Details
Main Authors: Sachiko Noda, Shigeto Sato, Takahiro Fukuda, Norihiro Tada, Yasuo Uchiyama, Keiji Tanaka, Nobutaka Hattori
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Parkin
Mitochondria
Dopaminergic neuron
Aging
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119303924

Internet

http://www.sciencedirect.com/science/article/pii/S0969996119303924

Similar Items