A straightforward approach towards combined α-amino and α-hydroxy acids based on Passerini reactions

Complex amino acids with an α-acyloxycarbonyl functionality in the side chain are easily available through epoxide opening by chelated enolates and subsequent oxidation/Passerini reaction. This protocol works with both, aldehyde and ketone intermediates, as long as the ketones are activated by elect...

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Bibliographic Details
Main Authors: Ameer F. Zahoor, Sarah Thies, Uli Kazmaier
Format: Article
Language:English
Published: Beilstein-Institut 2011-09-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.7.151