Self-antigen MASH2 combined with the AS15 immunostimulant induces tumor protection in colorectal cancer mouse models.

Self-antigen MASH2 combined with the AS15 immunostimulant induces tumor protection in colorectal cancer mouse models.

Human achaete scute homolog 2 (HASH2) and its murine ortholog MASH2 are potential targets for colorectal cancer immunotherapy. We assessed immunogenicity and antitumor potential of recombinant MASH2 protein combined with AS15 immunostimulant (recMASH2+AS15) in CB6F1 and Apc+/Min-FCCC mice. CB6F1 mic...

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Bibliographic Details
Main Authors: Clément R Rioux, Margie L Clapper, Harry S Cooper, Jean Michaud, Natalie St Amant, Hossein Koohsari, Laura Workman, Esther Kaunga, Harvey Hensley, Anthony Pilorget, Catherine Gerard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0210261

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https://doi.org/10.1371/journal.pone.0210261

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