A Transgenic Mouse Model of Eccentric Left Ventricular Hypertrophy With Preserved Ejection Fraction Exhibits Alterations in the Autophagy-Lysosomal Pathway

A Transgenic Mouse Model of Eccentric Left Ventricular Hypertrophy With Preserved Ejection Fraction Exhibits Alterations in the Autophagy-Lysosomal Pathway

The ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are the main proteolytic systems involved in cellular homeostasis. Since cardiomyocytes, as terminally differentiated cells, lack the ability to share damaged proteins with their daughter cells, they are especially relia...

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Bibliographic Details
Main Authors: Kristin Wenzel, Elisabeth Krämer, Birgit Geertz, Lucie Carrier, Stephan B. Felix, Stephanie Könemann, Saskia Schlossarek
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Physiology
Subjects:
autophagy-lysosomal pathway
cardiomyopathy
left ventricular hypertrophy
protein degradation
ubiquitin-proteasome system
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.614878/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.614878/full

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