Inhibition of N-Type Calcium Channels by Fluorophenoxyanilide Derivatives

Inhibition of N-Type Calcium Channels by Fluorophenoxyanilide Derivatives

A set of fluorophenoxyanilides, designed to be simplified analogues of previously reported ω-conotoxin GVIA mimetics, were prepared and tested for N-type calcium channel inhibition in a SH-SY5Y neuroblastoma FLIPR assay. N-type or Cav2.2 channel is a validated target for the treatment of refractory...

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Bibliographic Details
Main Authors: Ellen C. Gleeson, Janease E. Graham, Sandro Spiller, Irina Vetter, Richard J. Lewis, Peter J. Duggan, Kellie L. Tuck
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Marine Drugs
Subjects:
N-type calcium channel
Cav2.2
channel blocker
pain
FLIPR
Online Access:http://www.mdpi.com/1660-3397/13/4/2030

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http://www.mdpi.com/1660-3397/13/4/2030

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