IL-27-induced gene expression is downregulated in HIV-infected subjects.
OBJECTIVE: To characterize the effect of HIV infection on IL-27-induced gene expression. DESIGN: During HIV infection, cytokine expression and function become deregulated. IL-27 is an important modulator of inflammatory responses. Interestingly, IL-27 can inhibit HIV replication in T cells and monoc...
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Public Library of Science (PLoS)