IL-27-induced gene expression is downregulated in HIV-infected subjects.
OBJECTIVE: To characterize the effect of HIV infection on IL-27-induced gene expression. DESIGN: During HIV infection, cytokine expression and function become deregulated. IL-27 is an important modulator of inflammatory responses. Interestingly, IL-27 can inhibit HIV replication in T cells and monoc...
Main Authors: | Christina Guzzo, Wilma M Hopman, Nor Fazila Che Mat, Wendy Wobeser, Katrina Gee |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3458084?pdf=render |
Similar Items
-
Novel Functions of IL-27 in Innate Immunity: Characterization of IL-27-induced Inflammatory Responses in Human Monocytes and Impact of HIV Infection on IL-27 Expression and Function
by: Guzzo, Christina
Published: (2012) -
IMPACT OF RNA VIRUSES ON THE REGULATION OF IL-23 IN MOUSE AND HUMAN MODELS OF INFECTION.
by: CHE MAT, NOR FAZILA
Published: (2011) -
IL-27, IL-30, and IL-35: A Cytokine Triumvirate in Cancer
by: Olena Kourko, et al.
Published: (2019-10-01) -
Plasma interleukin-27 (IL-27) levels are not modulated in patients with chronic HIV-1 infection.
by: Sanjay Swaminathan, et al.
Published: (2014-01-01) -
Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes
by: Carlene Petes, et al.
Published: (2018-02-01)