ER Stress via CHOP Pathway is Involved in FK506-Induced Apoptosis in Rat Fibroblasts

ER Stress via CHOP Pathway is Involved in FK506-Induced Apoptosis in Rat Fibroblasts

Background/Aims: Hypertrophic scars (HS) formation results from reduced apoptosis and increased proliferation of fibroblasts. Therefore, apoptosis of fibroblasts is a key target for the development of novel therapeutic strategies for HS. Previous reports demonstrated that FK506 could attenuate scar...

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Bibliographic Details
Main Authors: Jian Tang, Yingbin Ge, Lei Yang, Xinyu Xu, Tao Sui, Dawei Ge, Jun Que, Xiaojian Cao
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
FK506
Fibroblast
Apoptosis
ER stress
CHOP
PERK
Online Access:http://www.karger.com/Article/FullText/447894

Internet

http://www.karger.com/Article/FullText/447894

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