Follistatin supplementation induces changes in CDX2 CpG methylation and improves in vitro development of bovine SCNT preimplantation embryos

Follistatin supplementation induces changes in CDX2 CpG methylation and improves in vitro development of bovine SCNT preimplantation embryos

Abstract Caudal Type Homeobox 2 (CDX2) is a key regulator of trophectoderm formation and maintenance in preimplantation embryos. We previously demonstrated that supplementation of exogenous follistatin, during in vitro culture of bovine IVF embryos, upregulates CDX2 expression, possibly, via alterat...

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Bibliographic Details
Main Authors: Mohamed Ashry, Chunyan Yang, Sandeep K. Rajput, Joseph K. Folger, Jason G. Knott, George W. Smith
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Reproductive Biology and Endocrinology
Subjects:
Bovine preimplantation embryos
SCNT
CDX2
DNA methylation
Follistatin
Online Access:https://doi.org/10.1186/s12958-021-00829-7

Internet

https://doi.org/10.1186/s12958-021-00829-7

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