Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress

Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress

Parkinson’s disease (PD) is one of the most common age-related neurodegenerative diseases. This pathology causes a significant loss of dopaminergic neurons in the Substantia Nigra. Several reports have claimed a role of defective nuclear and mitochondrial DNA repair pathways in PD etio...

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Bibliographic Details
Main Authors: Sarah Ciccone, Emiliano Maiani, Giovanna Bellusci, Marc Diederich, Stefania Gonfloni
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:International Journal of Molecular Sciences
Subjects:
neurodegenerative diseases
Parkinson&#8217
s disease (PD)
base excision repair (BER)
mitochondria
oxidative stress
reactive oxidative species (ROS)
reactive nitrogen species (RNS)
c-Abl
reduced glutathione (GSH)
oxidized glutathione (GSS-)
Online Access:http://www.mdpi.com/1422-0067/14/2/2388

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http://www.mdpi.com/1422-0067/14/2/2388

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