Exogenous α-synuclein hinders synaptic communication in cultured cortical primary rat neurons.

Exogenous α-synuclein hinders synaptic communication in cultured cortical primary rat neurons.

Amyloid aggregates of the protein α-synuclein (αS) called Lewy Bodies (LB) and Lewy Neurites (LN) are the pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. We have previously shown that high extracellular αS concentrations can be toxic to cells and that neurons take...

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Bibliographic Details
Main Authors: G C Hassink, C C Raiss, I M J Segers-Nolten, R J A van Wezel, V Subramaniam, J le Feber, M M A E Claessens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5863964?pdf=render

Internet

http://europepmc.org/articles/PMC5863964?pdf=render

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