MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential

MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential

Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) is part of a system of signals involved in controlling T-cell activation. Targeting and agonizing GITR in mice promotes antitumor immunity by enhancing the function of effector T cells and inhibiting regulatory T cells. Her...

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Bibliographic Details
Main Authors: Natalie J. Tigue, Lisa Bamber, John Andrews, Samantha Ireland, James Hair, Edward Carter, Sudharsan Sridharan, Jelena Jovanović, D. Gareth Rees, Jeremy S. Springall, Emilie Solier, Yi-Ming Li, Matthieu Chodorge, David Perez-Martinez, Daniel R. Higazi, Michael Oberst, Maureen Kennedy, Chelsea M. Black, Li Yan, Martin Schwickart, Shaun Maguire, Jennifer A. Cann, Lolke de Haan, Lesley L. Young, Tristan Vaughan, Robert W. Wilkinson, Ross Stewart
Format: Article
Language:English
Published: Taylor & Francis Group 2017-03-01
Series:OncoImmunology
Subjects:
agonist
gitr
gitrl
hexamer
medi1873
t cell
tumor
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1280645

Internet

http://dx.doi.org/10.1080/2162402X.2017.1280645

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