IL-27 Mediates PD-L1 Expression and Release by Human Mesothelioma Cells

IL-27 Mediates PD-L1 Expression and Release by Human Mesothelioma Cells

Malignant mesothelioma (MM) is a rare tumor with an unfavorable prognosis. MM genesis involves asbestos-mediated local inflammation, supported by several cytokines, including IL-6. Recent data showed that targeting PD-1/PD-L1 is an effective therapy in MM. Here, we investigated the effects of IL-6 t...

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Bibliographic Details
Main Authors: Grazia Carbotti, Beatrice Dozin, Stefania Martini, Chiara Giordano, Francesca Scordamaglia, Michela Croce, Gilberto Filaci, Silvano Ferrini, Marina Fabbi
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
mesothelioma
IL-27
PD-L1
IL-6
STAT1/3
pleural effusion
Online Access:https://www.mdpi.com/2072-6694/13/16/4011

Internet

https://www.mdpi.com/2072-6694/13/16/4011

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