NFAT Signaling in Osteoblasts Regulates the Hematopoietic Niche in the Bone Microenvironment

Osteoblasts support hematopoietic cell development, including B lymphopoiesis. We have previously shown that the nuclear factor of activated T cells (NFAT) negatively regulates osteoblast differentiation and bone formation. Interestingly, in smooth muscle, NFAT has been shown to regulate the express...

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Bibliographic Details
Main Authors: Cheryl L. Sesler, Majd Zayzafoon
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2013/107321