Terpenes increase the lipid dynamics in the Leishmania plasma membrane at concentrations similar to their IC50 values.

Terpenes increase the lipid dynamics in the Leishmania plasma membrane at concentrations similar to their IC50 values.

Although many terpenes have shown antitumor, antibacterial, antifungal, and antiparasitic activity, the mechanism of action is not well established. Electron paramagnetic resonance (EPR) spectroscopy of the spin-labeled 5-doxyl stearic acid revealed remarkable fluidity increases in the plasma membra...

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Bibliographic Details
Main Authors: Heverton Silva Camargos, Rodrigo Alves Moreira, Sebastião Antonio Mendanha, Kelly Souza Fernandes, Miriam Leandro Dorta, Antonio Alonso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4125203?pdf=render

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http://europepmc.org/articles/PMC4125203?pdf=render

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