Molecular mechanism of calcium induced trimerization of C1q-like domain of otolin-1 from human and zebrafish

Abstract The C1q superfamily includes proteins involved in innate immunity, insulin sensitivity, biomineralization and more. Among these proteins is otolin-1, which is a collagen-like protein that forms a scaffold for the biomineralization of inner ear stones in vertebrates. The globular C1q-like do...

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Bibliographic Details
Main Authors: Rafał Hołubowicz, Andrzej Ożyhar, Piotr Dobryszycki
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-92129-8