Intraventricular dopamine infusion alleviates motor symptoms in a primate model of Parkinson's disease

Intraventricular dopamine infusion alleviates motor symptoms in a primate model of Parkinson's disease

Background: Continuous compensation of dopamine represents an ideal symptomatic treatment for Parkinson's disease (PD). The feasibility in intracerebroventricular administration (i.c.v.) of dopamine previously failed because of unresolved dopamine oxidation. Objectives: We aim to test the feasi...

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Bibliographic Details
Main Authors: Caroline Moreau, Anne Sophie Rolland, Elsa Pioli, Qin Li, Pascal Odou, Christine Barthelemy, Damien Lannoy, Alexandre Demailly, Natacha Carta, Vincent Deramecourt, Florent Auger, Gregory Kuchcinski, Charlotte Laloux, Luc Defebvre, Regis Bordet, James Duce, Jean Christophe Devedjian, Erwan Bezard, Matthieu Fisichella, David Devos
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Dopamine in anaerobia
Continuous dopaminergic stimulation
Motor fluctuations with dyskinesia
Neurosurgical treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120301212

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http://www.sciencedirect.com/science/article/pii/S0969996120301212

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