Charged residues next to transmembrane regions revisited: “Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”

Charged residues next to transmembrane regions revisited: “Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”

Abstract Background Transmembrane helices (TMHs) frequently occur amongst protein architectures as means for proteins to attach to or embed into biological membranes. Physical constraints such as the membrane’s hydrophobicity and electrostatic potential apply uniform requirements to TMHs and their f...

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Bibliographic Details
Main Authors: James Alexander Baker, Wing-Cheong Wong, Birgit Eisenhaber, Jim Warwicker, Frank Eisenhaber
Format: Article
Language:English
Published: BMC 2017-07-01
Series:BMC Biology
Subjects:
Amino acid distribution
Genome-wide statistical study
Membrane protein
Negative-not-inside/negative-outside rule
Protein topology prediction
Proteomics
Online Access:http://link.springer.com/article/10.1186/s12915-017-0404-4

Internet

http://link.springer.com/article/10.1186/s12915-017-0404-4

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