A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP

A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP

Compelling evidence suggests that accumulation and aggregation of alpha-synuclein (α-syn) contribute to the pathogenesis of Parkinson's disease (PD). Here, we describe a novel Bacterial Artificial Chromosome (BAC) transgenic model, in which we have expressed wild-type human α-syn fused to green...

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Bibliographic Details
Main Authors: Christian Hansen, Tomas Björklund, Geraldine H. Petit, Martin Lundblad, Reena Prity Murmu, Patrik Brundin, Jia-Yi Li
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113001319

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http://www.sciencedirect.com/science/article/pii/S0969996113001319

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