PD-L1 Improves Motor Function and Alleviates Neuropathic Pain in Male Mice After Spinal Cord Injury by Inhibiting MAPK Pathway

PD-L1 Improves Motor Function and Alleviates Neuropathic Pain in Male Mice After Spinal Cord Injury by Inhibiting MAPK Pathway

BackgroundTraumatic spinal cord injury (SCI) causes severe motor dysfunction and persistent central neuropathic pain (Nep), which has not yet been effectively cured. Programmed cell death ligand-1 (PD-L1) is typically produced by cancer cells and contributes to the immune-suppressive in tumor microe...

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Bibliographic Details
Main Authors: Fanqi Kong, Kaiqiang Sun, Jian Zhu, Fudong Li, Feng Lin, Xiaofei Sun, Xi Luo, Changzhen Ren, Lantao Lu, ShuJie Zhao, Jingchuan Sun, Yuan Wang, Jiangang Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
PD-L1
spinal cord injury
neuropathic pain
macrophages/microglial
polarization
ERK1/2, p38
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.670646/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.670646/full

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