Highly Selective Activation of Heat Shock Protein 70 by Allosteric Regulation Provides an Insight into Efficient Neuroinflammation Inhibition

Highly Selective Activation of Heat Shock Protein 70 by Allosteric Regulation Provides an Insight into Efficient Neuroinflammation Inhibition

Heat shock protein 70 (Hsp70) is widely involved in immune disorders, making it as an attractive drug target for inflammation diseases. Nonselective induction of Hsp70 upregulation for inflammation therapy could cause extensive interference in inflammation-unrelated protein functions, potentially re...

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Bibliographic Details
Main Authors: Li-Chao Wang, Li-Xi Liao, Hai-Ning Lv, Dan Liu, Wei Dong, Jian Zhu, Jin-Feng Chen, Meng-Ling Shi, Ge Fu, Xiao-Min Song, Yong Jiang, Ke-Wu Zeng, Peng-Fei Tu
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:EBioMedicine
Subjects:
Heat shock protein 70 (Hsp70)
Handelin
Drug target
Covalent modification
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417303286

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http://www.sciencedirect.com/science/article/pii/S2352396417303286

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