Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells

Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells

Despite significant efforts to improve pancreatic ductal adenocarcinoma (PDAC) clinical outcomes, overall survival remains dismal. The poor response to current therapies is partly due to the existence of pancreatic cancer stem cells (PaCSCs), which are efficient drivers of PDAC tumorigenesis, metast...

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Bibliographic Details
Main Authors: Timothy P. Cash, Sonia Alcalá, María del Rosario Rico-Ferreira, Elena Hernández-Encinas, Jennifer García, María Isabel Albarrán, Sandra Valle, Javier Muñoz, Sonia Martínez-González, Carmen Blanco-Aparicio, Joaquín Pastor, Manuel Serrano, Bruno Sainz
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
compound library
cancer stem cells
pancreatic ductal adenocarcinoma
lysosomal membrane permeabilization
patient-derived xenografts
Online Access:https://www.mdpi.com/2072-6694/12/7/1790

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https://www.mdpi.com/2072-6694/12/7/1790

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