Real-time imaging of intestinal bacterial β-glucuronidase activity by hydrolysis of a fluorescent probe

Real-time imaging of intestinal bacterial β-glucuronidase activity by hydrolysis of a fluorescent probe

Abstract Intestinal bacterial β-glucuronidase (βG) hydrolyzes glucuronidated metabolites to their toxic form in intestines, resulting in intestinal damage. The development of a method to inhibit βG is thus important but has been limited by the difficulty of directly assessing enzyme activity in live...

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Bibliographic Details
Main Authors: Michael Chen, Kai-Wen Cheng, Yi-Jou Chen, Chang-Hung Wang, Ta-Chun Cheng, Kuo-Chien Chang, An-Pei Kao, Kuo-Hsiang Chuang
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03252-4

Internet

https://doi.org/10.1038/s41598-017-03252-4

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