Estrogen Enhances Matrix Synthesis in Nucleus Pulposus Cell through the Estrogen Receptor β-p38 MAPK Pathway

Estrogen Enhances Matrix Synthesis in Nucleus Pulposus Cell through the Estrogen Receptor β-p38 MAPK Pathway

Background/Aims: Matrix homeostasis within the disc nucleus pulposus (NP) tissue is important for disc function. Increasing evidence indicates that sex hormone can influence the severity of disc degeneration. This study was aimed to study the role of 17β-estradiol (E2) in NP matrix synthesis and its...

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Bibliographic Details
Main Authors: Pei Li, Yuan Xu, Yibo Gan, Liyuan Wang, Bin Ouyang, Chengmin Zhang, Lei Luo, Chen Zhao, Qiang Zhou
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Matrix
17β-estradiol
Estrogen receptor β
Nucleus pulposus
p38 MAPK
Online Access:http://www.karger.com/Article/FullText/447915

Internet

http://www.karger.com/Article/FullText/447915

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