Inhibition of the receptor tyrosine kinase ROR1 by anti-ROR1 monoclonal antibodies and siRNA induced apoptosis of melanoma cells.

Inhibition of the receptor tyrosine kinase ROR1 by anti-ROR1 monoclonal antibodies and siRNA induced apoptosis of melanoma cells.

The receptor tyrosine kinase (RTK) ROR1 is overexpressed and of importance for the survival of various malignancies, including lung adenocarcinoma, breast cancer and chronic lymphocytic leukemia (CLL). There is limited information however on ROR1 in melanoma. In the present study we analysed in seve...

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Main Authors: Mohammad Hojjat-Farsangi, Fatemeh Ghaemimanesh, Amir Hossein Daneshmanesh, Ali-Ahmad Bayat, Jafar Mahmoudian, Mahmood Jeddi-Tehrani, Hodjatallah Rabbani, Hakan Mellstedt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3620154?pdf=render

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http://europepmc.org/articles/PMC3620154?pdf=render

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