Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia.

Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia.

Most patients with acute lymphoblastic leukemia (ALL) respond well to standard chemotherapy-based treatments. However a significant proportion of patients, particularly adult patients, relapse with the majority dying of leukemia. FTY720 is an immunosuppressive drug that was recently approved for the...

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Bibliographic Details
Main Authors: Craig T Wallington-Beddoe, Anthony S Don, John Hewson, Qiao Qiao, Rachael A Papa, Richard B Lock, Kenneth F Bradstock, Linda J Bendall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3343039?pdf=render

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http://europepmc.org/articles/PMC3343039?pdf=render

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