A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1

A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1

Abstracts The E3 ligase HERC4 is overexpressed in human breast cancer and its expression levels correlated with the prognosis of breast cancer patients. However, the roles of HERC4 in mammary tumorigenesis remain unclear. Here we demonstrate that the knockdown of HERC4 in human breast cancer cells d...

Full description

Bibliographic Details
Main Authors: Youqin Xu, Kaiyuan Ji, Meng Wu, Bingtao Hao, Kai-tai Yao, Yang Xu
Format: Article
Language:English
Published: SpringerOpen 2019-02-01
Series:Protein & Cell
Subjects:
E3 ligase
tumorigenesis
ubiquitination
tumor suppressor
miRNA
Online Access:http://link.springer.com/article/10.1007/s13238-019-0607-2

Internet

http://link.springer.com/article/10.1007/s13238-019-0607-2

Similar Items